-
Research Paper Review: Subareolar Tissue Biopsy and Occult Nipple Involvement in Nipple-Sparing Mastectomies
Nipple-sparing mastectomies are preferred for patients with breast cancer that do not involve the nipple-areolar complex. In practice, subareolar tissue is submitted for intraoperative frozen sections, and the pathologist examines the specimen for microscopic signs of malignancy. This paper examines the reliability of this method in detecting occult nipple disease and the tumor features that predict a positive biopsy.