Nipple-sparing mastectomies are preferred for patients with breast cancer that do not involve the nipple-areolar complex. In practice, subareolar tissue is submitted for intraoperative frozen sections, and the pathologist examines the specimen for microscopic signs of malignancy. This paper examines the reliability of this method in detecting occult nipple disease and the tumor features that predict a positive biopsy.
Imprint cytology is a valuable tool in evaluating specimens received for lymphoma workup. Whether the specimen is abundant or scant, imprint cytology helps in triaging tissue allocation for subsequent studies.